Linear models for joint association and linkage QTL mapping

Joint QTL Linkage Mapping for Multiple-Cross Mating Design Sharing One Common Parent

BACKGROUND Nested association mapping (NAM) is a novel genetic mating design that combines the advantages of linkage analysis and association mapping. This design provides opportunities to study the inheritance of complex traits, but also requires more advanced statistical methods. In this paper, we present the detailed algorithm of a QTL linkage mapping method suitable for genetic populations ...

Linkage and QTL mapping for Sus scrofa chromosome

Linkage and QTL maps of Sus scrofa chromosome 17 (SSC17) were analysed with five markers and in three F2 families based on Wild Boar (W), Meishan (M) and Pietrain (P) crosses. The maps were similar across the three families and agree well with published maps. In the M · P family, new quantitative trait loci (QTLs) for growth and fat deposition were located in the vicinity of GHRH, whereas in th...

linkage disequilibrium and association mapping

QTL Mapping II: Outbred Populations and Association Mapping

Joint linkage and linkage disequilibrium mapping in natural populations.

A new strategy for studying the genome structure and organization of natural populations is proposed on the basis of a combined analysis of linkage and linkage disequilibrium using known polymorphic markers. This strategy exploits a random sample drawn from a panmictic natural population and the open-pollinated progeny of the sample. It is established on the principle of gene transmission from ...